Linear 1 3-diarylpropanoids
AdipoGen Phloretin
Chemical. CAS 60-82-2. Formula C15H14O5. MW 274.27. Phloretin is a natural dihydrochalcone, originally identified from the apple tree, and is a metabolite of phlorizin. It has numerous pharmacological effects, including anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and cytoprotective properties. Phloretin is a potent antioxidant, scavenging peroxynitrite ONOO- and/or suppressing lipid peroxidation, which contributes to the many biological properties. Phloretin has anti-aging and depigmenting effects, making it also attractive for dermatological research and application. Phloretin attacks a number of molecular targets, modulating different intracellular signaling pathways, including NF-kappaB, MAPK, Nrf2, and AMPK. It can modulate Ca2 channels, PKC, GLUTs, SGLTs and other targets. The anticancer potential is based on antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities.
Medchemexpress LLC Phlorizin | 60-81-1 | MFCD00006652 | ≥98% | 436.43 | 1 G
Phlorizin is a biochemical reagent that acts as a non-selective SGLT inhibitor (hSGLT1 Ki: 300 nM, hSGLT2 Ki: 39 nM) and a Na+/K+-ATPase inhibitor. It is suitable for use as a biological material or organic compound in life science research.
- Non-selective SGLT inhibitor
- Na+/K+-ATPase inhibitor
- Classification: Flavonoids, Phenols, Polyphenols, Dihydrochalcones
- Source: Malus pumila Mill. (Rosaceae), Plants
- Targets: SGLT, Na+/K+ ATPase
- Research areas: Metabolic disease
Medchemexpress LLC 2-propen-1-one, 1,3-diphenyl- | 94-41-7 | 100.0% | 1 ML
Chalcone (2-Propen-1-one, 1,3-diphenyl-) is an α,β-unsaturated ketone used as a synthetic building block and research reagent. It is supplied as a solid or as a prepared 10 mM solution in DMSO, 1 ML, for screening and synthesis applications.
- Offered as solid and as 10 mM solution in DMSO, 1 ML.
- High purity (99.98% by HPLC) suitable for research use.
- Commonly used for synthesis of chalcone derivatives and biological screening.
- Provided with certificate of analysis documenting identity and purity.
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 25 G
4'-Methoxychalcone regulates adipocyte differentiation by activating PPARγ. It also modulates the expression and secretion of various adipokines in adipose tissue, which are involved in insulin sensitivity. The compound has shown antiproliferative activity against several human cancer cell lines, including A2780, CAL-51, HCT-116, and HT-29, and cytotoxicity against DLD-1 and FHC cells.
- Regulates adipocyte differentiation through PPARγ activation.
- Modulates adipokine expression and secretion in adipose tissue, impacting insulin sensitivity.
- Exhibits antiproliferative activity against human cancer cell lines.
- Cytotoxic to certain human cell lines.
- Originates from plants, specifically Piper nigrum Linn.
Medchemexpress LLC 4'-Methoxychalcone | 959-23-9 | 99.8% | 100 G
This product, 4'-Methoxychalcone, regulates adipocyte differentiation through PPARγ activation. It also modulates the expression and secretion of various adipokines in adipose tissue that are involved in insulin sensitivity.
- Regulates adipocyte differentiation
- Activates PPARγ
- Modulates adipokine expression related to insulin sensitivity
- Stable under recommended storage conditions
- White to light yellow solid appearance
- High purity of 99.8%
Medchemexpress LLC Avobenzone | 70356-09-1 | 98.0% | 5 G
Avobenzone, a dibenzoylmethane compound, is one of the most widely used filters in sunscreens for skin photoprotection in the UVA band. It is also an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist.
- Promotes adipogenesis in hBM-MSCs
- Up-regulates mRNA levels of PPARγ during adipogenesis
- Inhibits proliferative activities of human trophoblast cells
- Induces apoptosis in HTR8/SVneo cells
- Shows weak ERα agonism and weak AR antagonism
Apexbio Technology LLC Avobenzone 70356-09-1 200mg
Avobenzone (70356-09-1) is a small-molecule agonist targeting estrogen receptor (ER ) It is designed to bind directly to ER thereby modulating endocrine signaling pathways Avobenzone exerts its biological activity primarily through direct receptor binding and estrogenic agonist activity Based on these properties Avobenzone holds research potential in studies investigating endocrine-disrupting chemicals mechanisms of photoprotection UV-induced cellular damage and skin pathology
Medchemexpress LLC 1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one | 149732-52-5 | 292.33 | 5 MG
1,7-Bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one is a potent nucleocapsid (N) protein inhibitor isolated from *Curcuma kwangsiensis*. It demonstrates excellent antiviral activity against HCoV-OC43 and SARS-CoV-2.
- Inhibits nucleocapsid (N) protein
- Exhibits antiviral activity against HCoV-OC43 and SARS-CoV-2
- Active against various cell lines (KB, PC-12, Vero)